GLP1R fluorescent probe
Tag-lite GLP1 receptor fluorescent probe
The GLP1 receptor is a GPCR which role is to potentiate the glucose-induced secretion of insulin from pancreatic beta cells, increase insulin expression, inhibit beta-cell apoptosis, promote beta-cell neogenesis.
This HEK293 stable cell line expresses the GLP1 receptor fused to a SNAP-Tag. Labeled with Terbium, the cells can be used in a Tag-lite receptor binding protocol.
Examples of data obtained using glucagon GLP1-R expressing stable cells (HEK), labelled with terbium in Tag-lite buffer (LABMED) and their matching fluorescent ligand (L0030RED). Exendin 4 was used as reference ligand. Results may vary from one HTRF® compatible reader to another.
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