Alpha-Synuclein aggregation Kit
Alpha-Synuclein aggregation detection in cell and brain extracts
Tau proteins are required to stabilize microtubules through tubulin association. Deregulation of Tau expression, aggregation, and subsequent phosphorylation have been correlated to the onset of pathologies linked to the nervous system such as Alzheimer's and Parkinson's. The Tau aggregation assay detects human Tau aggregates rapidly in brain tissues and cell cultures. This kit is part of our Tau range, including phosphorylated Tau detection and total Tau measurement (MAP-Tau).
Triple-transgenic mice (Tau / PSEN2 / APP) were used as Alzheimer models. These mice develop an Alzheimer-like pathology that starts at 10 months old and progresses over time. The aim of this experiment was to detect differences in the quantity of Tau aggregates between 10 and 14 month-old mice, in the earlier stages of the disease. The graph shows that assay sensitivity enables clear discrimination between the early stages of the fibrillation process. These results correlate with those obtained for Tau phosphorylation.
How HTRF compares to Western Blot and ELISA
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Tau aggregation in Alzheimer’s disease pathogenesis addressed with HTRF assays
See how peer researchers challenge tau aggregation with HTRF - Application Notes
Molecular basis of neuroinflammation and neurodegeneration diseases
The essential guide for extending your knowledge on the molecular mechanisms of neurodegenerative diseases - Guides
On-demand webinar: Linking Neuroinflammation and Neurodegeneration
New insight into neuroinflammation research - Videos
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